Article Text

PDF

Plasma catestatin level in patients with acute myocardial infarction and its correlation with ventricular remodelling
  1. Lei Meng1,
  2. Jie Wang1,
  3. Wen-hui Ding1,
  4. Ping Han2,
  5. Ying Yang1,
  6. Li-tong Qi1,
  7. Bao-wei Zhang1
  1. 1Department of Cardiology, Peking University First Hospital, Beijing, P.R. China
  2. 2Department of Cardiology, Beijing Haidian Hospital, Beijing, P.R. China
  1. Correspondence to Wen-hui Ding, Department of Cardiology, Peking University First Hospital, Beijing 100034, P.R. China; menglei{at}medmail.com.cn

Abstract

Background The evaluation of ventricular remodelling and functional recovery is essential in predicting the prognosis of patients with acute myocardial infarction (AMI).

Objective To determine the plasma catestatin level in patients with AMI, and investigate the association between plasma catestatin and heart function, and with left ventricular remodelling (LVR).

Methods Fifty-eight consecutive patients who were admitted within 12 h of the onset of their ST-segment elevation myocardial infarction symptoms between 1 October 2009 and 30 June 2011 were prospectively recruited. Circulating catestatin was measured by ELISA. All patients underwent an echocardiography examination during the first week; 31 patients had a second echocardiography examination 3 months after the myocardial infarction.

Results Plasma catestatin at the time of admission was significantly higher in patients than in normal controls. The level increased further in the first week after AMI. Three months after AMI, the plasma catestatin level of patients was comparable to that of normal controls. The plasma level of catestatin correlated with anterior AMI and left ventricular ejection fraction (LVEF) in the acute stage. Compared with patients without LVR, those with LVR had significantly higher level of plasma brain natriuretic peptide on day 7 and a significantly higher level of plasma catestatin on admission and on days 3 and 7 (p=0.033, p=0.001, p=0.006, p=0.021, respectively).

Conclusions Plasma catestatin levels were raised after AMI. An early increase of catestatin correlated with anterior AMI and LVEF. Plasma catestatin after the onset of AMI might be associated with the magnitude of progressive ventricular remodelling 3 months after AMI.

Statistics from Altmetric.com

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.