Postgrad Med J 89:181 doi:10.1136/postgradmedj-2012-131513
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Osler–Weber–Rendu syndrome simulating pulmonary metastasis

  1. Edson Marchiori2
  1. 1Department of Clinical Medicine, Federal University of Bahia, Salvador, Brazil
  2. 2Department of Radiology, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
  1. Correspondence to Professor Edson Marchiori, Department of Radiology, Federal University of Rio de Janeiro, 438 Rua Thomaz Cameron, Valparaiso, Petrópolis, Rio de Janeiro CEP 25685.120, Brazil; edmarchiori{at}
  • Received 28 September 2012
  • Revised 5 November 2012
  • Accepted 20 December 2012
  • Published Online First 10 January 2013

Osler–Weber–Rendu syndrome, also known as hereditary haemorrhagic telangiectasia (HHT), is an autosomal dominant disorder of abnormal blood vessel formation manifesting as telangiectasias and arteriovenous malformations (AVMs). The criteria for the diagnosis of HHT are epistaxis, multiple telangiectasias at mucocutaneous surfaces, AVMs in larger organ systems, and a family history of HHT.1–3 Recurrent epistaxis is the most common presenting complaint.

Cerebral AVMs occur in about 10–20% of patients with HHT, and are associated with high mortality and morbidity due to stroke or brain abscess. MRI is currently the best way to detect these vascular malformations. Gastrointestinal telangiectasia, including angiodysplasia, is a common manifestation of HHT. Recurrent upper or lower gastrointestinal bleeding occurs in approximately 20% of patients with HHT and …