"Xanthelasma palpebrarum -a cutaneous sign of increased cardiovascular risk"-still a misunderstanding
Xanthelasma palpebrarum ia a sharply demarcated yellowish flat plaque om the upper and lower eyelid, mostly near the inner canthus.In a prospective study done in Copenhagen University revealed that xanthelasme palpebrarum predict risk of myocardial infarction, ischaemic heart disease, severe atherosclerosis, and death in the general population.In present study which is a cross-sectional study revealed that xanthelasma is associated with increased proatherogenic markers thus there may be increased risk.Another study revealed that in patients with xanthelasma, no increase was observed in the rate or risk of cardiovascular disease, Moreover, no relationship was found between Lp (a) levels and xanthelasma though hyperlipidemia is common in patients with xanthelasma. so, i want to highlight few points.As xanthelasma is quite common in asian individuals we need a nation wide, age and sex match, cohort study to strenghthen the hypothesis.Another point is that we should go for an randomised controlled trial evaluating the role of statin in patients with xanthelasme palpebrarum without any other cardiovascular and cerebrovascular risk factors in reducing the risk of death due to cardiovascular and cerebrovascular causes compared to placebo.Thus we can strengthen our present view in support. References: 1. . Mette Christoffersen, Ruth Frikke-Schmidt, Peter Schnohr, Gorm B Jensen, B?rge G Nordestgaard, Anne Tybj?rg-Hansen. BMJ 2011; 343 doi: 10.1136/bmj.d5497.
2. Ozd?l S, Sahin S, Tokg?zo?lu L. Xanthelasma palpebrarum and its relation to atherosclerotic risk factors and lipoprotein (a). Int J Dermatol. 2008 Aug;47(8):785-9.
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