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Postgrad Med J 2009;85:9-14 doi:10.1136/pgmj.2008.069831
  • Review

Transforming growth factor β1 signalling, wound healing and repair: a multifunctional cytokine with clinical implications for wound repair, a delicate balance

  1. B R Klass1,
  2. A O Grobbelaar2,
  3. K J Rolfe1
  1. 1
    The RAFT Institute, Mount Vernon Hospital, Northwood, Middlesex, UK
  2. 2
    Department of Plastic and Reconstructive Surgery, The Royal Free Hospital, Hampstead, London, UK
  1. Dr K J Rolfe, The RAFT Institute, Mount Vernon Hospital, Northwood, Middlesex HA6 2RN, UK; rolfek{at}raft.ac.uk
  • Received 27 June 2008
  • Accepted 12 September 2008

Abstract

Transforming growth factor β1 (TGFβ1) is a multifunctional cytokine known to be involved in a number of human diseases. It is believed to play an important role in wound healing and repair, as it is a key regulator of the production and remodelling of the extracellular matrix through its effect on mesenchymal cells. Over the last few years, it has become evident that the signalling pathway of TGFβ is complex with numerous receptor–ligand interactions, intracellular pathways and a number of mechanisms, which not only control the signalling but may also decide the response to the TGFβ signal. This review focuses on TGFβ1 signalling and the role that TGFβ1 plays in wound healing, repair and scarring.

Footnotes

  • Competing interests: None.

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