Table 3
Genotypes and results of univariate analysis
| SNP (rs No)* | Genotype | Lung cancer | Smokingcontrols | Call rate (%) | UnivariateOR (95% CI) | p Value | Phenotype |
| α5-nAChR (rs 16969968) | AA | 68 (16%) | 45 (9%) | 1.8 (1.2 to 2.7) | 0.004 | Susceptibility | |
| AG/GG | 361 (84%) | 426 (91%) | |||||
| CYP 2E1 (rs 2031920) | TT/TC | 24 (6%) | 14 (3%) | 95 | 2.1 (1.0 to 4.3) | 0.03 | Susceptibility |
| CC | 379 (94%) | 463 (97%) | |||||
| Interleukin-18 (rs 360721) | CC | 237 (54%) | 208 (45%) | 96 | 1.4 (1.1 to 1.9) | 0.009 | Susceptibility |
| CG/GG | 201 (46%) | 250 (55%) | |||||
| Interleukin-8 (rs 4073) | TT | 129 (31%) | 109 (23%) | 96 | 1.5 (1.1 to 2.1) | 0.005 | Susceptibility |
| AT/AA | 284 (69%) | 367 (77%) | |||||
| Interleukin 1B (rs 16944) | GG | 215 (49%) | 212 (44%) | 99 | 1.2 (0.9 to 1.6) | 0.14 | Susceptibility |
| AA/AG | 224 (51%) | 269 (56%) | |||||
| ITGA11 (rs 2306022) | AA | 14 (3%) | 6 (1%) | 98 | 2.6 (0.9 to 7.6) | 0.04 | Susceptibility |
| GA/GG | 422 (97%) | 470 (99%) | |||||
| N-Acetylcysteine transferase 2 (rs 1799930) | GG | 239 (56%) | 222 (47%) | 97 | 1.4 (1.1 to 1.9) | 0.006 | Susceptibility |
| AA/AG | 189 (44%) | 253 (53%) | |||||
| α1-Antichymotrypsin | GG | 123 (28%) | 96 (20%) | 98 | 1.6 | 0.004 | Susceptibility |
| (rs 4934) | AG/AA | 312 (72%) | 383 (80%) | (1.2 to 2.2) | |||
| Cerberus 1 (rs 10115703) | AA/AG | 71 (16%) | 59 (12%) | 97 | 1.4 (0.9 to 2.0) | 0.10 | Susceptibility |
| GG | 363 (84%) | 413 (88%) | |||||
| DAT1 (rs 6413429) | GT/TT | 64 (15%) | 50 (10%) | 98 | 1.5 (1.0 to 2.3) | 0.04 | Susceptibility |
| GG | 367 (85%) | 431 (90%) | |||||
| TNFR1 (TNFRSF1A) (rs 1139417) | AA | 148 (36%) | 142 (30%) | 96 | 1.3 (1.0 to 1.8) | 0.05 | Susceptibility |
| AG/GG | 258 (64%) | 329 (70%) | |||||
| TLR9 (rs 5743836) | CC | 12 (3%) | 6 (1%) | 96 | 2.2 (0.8 to 6.6) | 0.12 | Susceptibility |
| CT/TT | 419 (97%) | 455 (99%) | |||||
| P73 (TP73) (rs 2273953) | CC | 219 (52%) | 292 (62%) | 96 | 0.65 (0.49 to 0.85) | 0.001 | Protective |
| TC/TT | 206 (48%) | 178 (38%) | |||||
| SOD3 (rs 1799895) | GG/GC | 4 (1%) | 15 (3%) | 96 | 0.28 (0.10 to 0.90) | 0.02 | Protective |
| CC | 425 (99%) | 451 (97%) | |||||
| ITGB3 (rs 2317676) | GG/GA | 44 (10%) | 77 (16%) | 98 | 0.59 (0.39 to 0.89) | 0.008 | Protective |
| AA | 391 (90%) | 403 (84%) | |||||
| DRD2 (rs 1799732) | CDel/Del.Del | 70 (16%) | 107 (22%) | 98 | 0.68 (0.48 to 0.96) | 0.02 | Protective |
| CC | 359 (84%) | 372 (78%) | |||||
| BCL2 (rs 2279115) | AA | 103 (24%) | 145 (31%) | 97 | 0.71 (0.53 to 0.97) | 0.03 | Protective |
| AC/CC | 328 (76%) | 330 (69%) | |||||
| XPD (ERCC2) (rs 13181) | GG | 60 (14%) | 81 (18%) | 96 | 0.74 (0.51 to 1.10) | 0.11 | Protective |
| GT/TT | 376 (86%) | 377 (82%) | |||||
| REV1 (REV1L) (rs 3087386) | CC | 128 (29%) | 163 (34%) | 98 | 0.79 (0.59 to 1.10) | 0.10 | Protective |
| TC/TT | 310 (71%) | 312 (66%) | |||||
| FasL (TNFSF6) (rs 763110) | TT | 53 (12%) | 78 (16%) | 98 | 0.72 (0.49 to 1.10) | 0.09 | Protective |
| TC/CC | 379 (88%) | 403 (84%) |
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*OMIM nomenclature.
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SNP, single nucleotide polymorphism.
