Article Text

PDF
Psoriasis: advances in pathophysiology and management
  1. A MacDonald,
  2. A D Burden
  1. Alan Lyell Dermatology Centre, Western Infirmary, Glasgow, UK
  1. Dr A MacDonald, Alan Lyell Dermatology Centre, Western Infirmary, Glasgow, G11 6NT, UK; alisonmacdonald21{at}doctors.org.uk

Abstract

Psoriasis is an inflammatory skin disease that affects 13 of Caucasian populations and may be persistent, disfiguring and stigmatising. There is a range of severity, but even when the affected body surface area is relatively limited the impact on day-to-day activities and social interactions may be significant. An understanding of the psychological burden and an appreciation that many patients are currently dissatisfied with their management has driven the development of more effective treatment. In recent years psoriasis has been the focus of intense investigation resulting in an improved understanding of the immunopathogenesis, and the development of new, targeted biological treatments.

  • biological
  • pathophysiology
  • psoriasis

Statistics from Altmetric.com

Footnotes

  • Competing interests: None

  • Abbreviations:
    APC
    antigen presenting cells
    DLQI
    Dermatology Life Quality Index
    FAE
    fumaric acid esters
    ICAM
    intracellular adhesion molecule
    IFN-
    interferon-
    IL
    interleukin
    MHC
    major histocompatibility complex
    NK
    natural killer
    NMSC
    non-melanoma skin carcinoma
    PASI
    Psoriasis Area and Severity Index
    PUVA
    psoralen plus ultraviolet A
    TGF-
    tumour growth factor-
    P3NP
    aminoterminal peptide of type III procollagen
    TLR
    toll-like receptors
    TNF-
    tumour necrosis factor-
    UVA
    ultraviolet A
    UVB
    ultraviolet B
    VEGF
    vascular derived endothelial growth factor

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.