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Sarcoid heart disease
  1. Simon W Dubrey1,
  2. Alex Bell2,
  3. Tarun K Mittal3
  1. 1
    Department of Cardiology, Hillingdon Hospital, Uxbridge, Middlesex, UK
  2. 2
    Department of Pathology, Harefield Hospital, Harefield, Middlesex, UK
  3. 3
    Department of Medical Imaging, Harefield Hospital
  1. Dr Simon W Dubrey, Hillingdon Hospital, Pield Heath Road, Uxbridge, Middlesex UB8 3NN, UK; simon.dubrey{at}thh.nhs.uk

Abstract

To this day the aetiology of sarcoidosis continues to elude definition. Partially as a consequence of this, little in the way of new therapies has evolved. The enigma of this condition is that, unusually for a disease with the potential for devastating consequences, many patients show spontaneous resolution and recover. Cardiac involvement can affect individuals of any age, gender or race and has a predilection for the conduction system of the heart. Heart involvement can also cause a dilated cardiomyopathy with consequent progressive heart failure. The most common presentation of this systemic disease is with pulmonary infiltration, but many cases will be asymptomatic and are detected on routine chest radiography revealing lymphadenopathy. Current advances lie in the newer methods of imaging and diagnosing this unusual heart disease. This review describes the pathology and diagnosis of this condition and the newer imaging techniques that have developed for determining cardiac involvement.

  • arrhythmia
  • cardiomyopathy
  • sarcoidosis

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Footnotes

  • Competing interests: None declared

  • Abbreviations:
    ACE
    angiotensin converting enzyme
    CT
    computed tomography
    FDG
    fluoro-2-deoxy-D glucose
    MRI
    magnetic resonance imaging
    PET
    positron emission tomography

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