Article Text

PDF
Screening for Addison’s disease in patients with type 1 diabetes mellitus and recurrent hypoglycaemia
  1. Taruna Likhari1,
  2. Saeed Magzoub1,
  3. Melanie J Griffiths1,
  4. Harit N Buch2,
  5. R Gama1,*
  1. 1Departments of Clinical Chemistry, New Cross Hospital, Wolverhampton, West Midlands, UK
  2. 2Departments of Diabetes, New Cross Hospital, Wolverhampton, West Midlands, UK
  1. Correspondence to:
 Professor R Gama
 Department of Clinical Chemistry, New Cross Hospital, Wolverhampton, West Midlands, WV10 0QP, UK; rousseau.gama{at}rwh-tr.nhs.uk

Abstract

Background: Addison’s disease may present with recurrent hypoglycaemia in subjects with type 1 diabetes mellitus. There are no data, however, on the prevalence of Addison’s disease presenting with recurrent hypoglycaemia in patients with diabetes mellitus.

Methods: Three year retrospective study of diabetic patients with “unexplained” recurrent hypoglycaemia investigated with a short Synacthen test to exclude adrenocortical insufficiency.

Results: 95 patients with type 1 diabetes mellitus were studied. Addison’s disease was identified as the cause of recurrent hypoglycaemia in one patient with type 1 diabetes mellitus.

Conclusion: Addison’s disease is a relatively rare but remedial cause of recurrent hypoglycaemia in patients with type 1 diabetes mellitus. A low threshold for investigating patients with type 1 diabetes mellitus and recurrent hypoglycaemia to detect Addison’s disease is therefore suggested.

Statistics from Altmetric.com

Footnotes

  • * Also Research Institute, Healthcare Sciences, Wolverhampton University, Wolverhampton, West Midlands, UK

  • Conflict of interest: none stated

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.