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Postgrad Med J 82:73-75 doi:10.1136/pgmj.2005.040105
  • Adverse drug reaction

Amiodarone toxicity presenting as pulmonary mass and peripheral neuropathy: the continuing diagnostic challenge

  1. I Azzam1,
  2. N Tov2,
  3. N Elias1,
  4. J E Naschitz1
  1. 1Department of Internal Medicine A, Bnai-Zion Medical Centre and “Rappaport Family” Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel
  2. 2Department of Internal Medicine C, Bnai-Zion Medical Center and “Rappaport Family” Faculty of Medicine, Technion-Israel Institute of Technology
  1. Correspondence to:
 Dr J E Naschitz
 Department of Internal Medicine A, Bnai-Zion Medical Centre, Haifa 31048, PO Box 4940, Israel; Naschitz{at}tx.technion.ac.il
  • Received 19 August 2005
  • Accepted 16 October 2005

Abstract

A 64 year old man receiving long term amiodarone treatment presented with dyspnea, cough, and weight loss. Radiographs and computed tomography showed a lung mass with associated multiple pulmonary nodules. Biopsies of the pulmonary mass showed foamy histiocytes without malignant cells. However, findings on FDG-PET scan were consistent with a malignant tumour. These findings on computed tomography and PET scan and the unusually late resolution of the pulmonary lesions after withdrawal of amiodarone treatment posed a challenging diagnostic problem.

Footnotes

  • Funding: none.

  • Conflicts of interest: none declared.