Mechanisms underlying recovery of motor function after stroke
- Correspondence to: Dr N S Ward Wellcome Department of Imaging Neuroscience, Institute of Neurology, 12 Queen Square, London WC1N 3BG, UK;
- Received 17 November 2004
- Accepted 10 January 2005
Neurological damage, and stroke in particular, is the leading cause of long term disability worldwide. There is growing interest in the part that central nervous system reorganisation plays in recovery of function. Techniques such as functional magnetic resonance imaging and transcranial magnetic stimulation permit the non-invasive study of the working human brain, and suggest that functionally relevant adaptive changes occur in the human brain after focal damage. An understanding of how these changes are related to recovery will facilitate the development of novel therapeutic techniques that are based on neurobiological principles and that are designed to minimise impairment in appropriately targeted patients suffering from stroke.
- fMRI, functional magnetic resonance imaging
- TMS, transcranial magnetic stimulation
- PET, positron emission tomography
- sMA, supplementary motor area
- CMA, cingulate motor area
- PMd, dorsolateral premotor cortex
Funding: the author is supported by The Wellcome Trust.
Conflicts of interest: none.