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Postgrad Med J 2005;81:194-195 doi:10.1136/pgmj.2003.018267
  • Adverse drug reaction

A woman who couldn’t speak: report of methotrexate neurotoxicity

  1. P Szawarski1,
  2. C S Chapman2
  1. 1Respiratory Medicine, Glenfield General Hospital, Leicester, UK
  2. 2Haematology Department, Leicester Royal Infirmary, Leicester, UK
  1. Correspondence to:
 Dr C S Chapman
 Haematology Department, Sandringham Building, Leicester Royal Infirmary, Infirmary Square, Leicester LE1 5WW, UK; claire.chapmanuhl-tr.nhs.uk
  • Received 29 December 2003
  • Accepted 14 July 2004

Abstract

The association between methotrexate therapy and idiosyncratic neurological complications is well recognised in children. This case illustrates the importance of considering the diagnosis of methotrexate toxicity in an adult patient with behavioural and speech disturbances, who received it by intrathecal route only and in whom the only indicator was an abnormal electroencephalographic study

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