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Postgrad Med J 80:560-570 doi:10.1136/pgmj.2003.017764
  • Review

Gene therapy in clinical medicine

  1. S M Selkirk
  1. Correspondence to:
 Dr S Selkirk
 Department of Neurology, University Hospital of Cleveland, Hanna House 5, 11100 Euclid Avenue, Cleveland, OH 44106, USA; stephen_selkirkhotmail.com
  • Received 9 December 2003
  • Accepted 13 March 2004

Abstract

Although the field of gene therapy has experienced significant setbacks and limited success, it is one of the most promising and active research fields in medicine. Interest in this therapeutic modality is based on the potential for treatment and cure of some of the most malignant and devastating diseases affecting humans. Over the next decade, the relevance of gene therapy to medical practices will increase and it will become important for physicians to understand the basic principles and strategies that underlie the therapeutic intervention. This report reviews the history, basic strategies, tools, and several current clinical paradigms for application.

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