Sarcoidosis and HIV infection: a case report and a review of the literature
- 1Division of Infectious Diseases, General Hospital and University of Padua, Italy
- 2Department of Pathology
- 3Radiologic Unit
- Correspondence to: Dr Anna Maria Cattelan, Division of Infectious Diseases, General Hospital and University of Padova, Via Giustiniani 2, 35128 Padova, Italy;
- Received 16 March 2003
- Accepted 24 May 2003
Sarcoidosis occurring in patients with AIDS is rare. This infrequent association has been attributed to the impairment of the immune system that may interfere with the granuloma formation in HIV infected patients. However, the introduction of highly active antiretroviral therapy (HAART) has brought about a substantial and sustained increase in CD4+ T lymphocyte cells, and has consequently led to the development of the so called “immune restoration disease”.
The case of an HIV infected man who developed sarcoidosis after the initiation of HAART is described. Skin nodule images and histological specimens are reported. The association between sarcoidosis and HIV infection is also reviewed.
- BAL, broncheoalveolar lavage
- HAART, highly active antiretroviral therapy
- SACE, serum angiotensin converting enzyme