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Postgrad Med J 2003;79:174-175 doi:10.1136/pmj.79.929.174
  • Case report

Haemoglobin Marseille-Long Island and interpretation of HbA1c: which HbA1c result is the “right answer”?

  1. C M Florkowski,
  2. T A Walmsley,
  3. S O Brennan,
  4. P M George
  1. Clinical Biochemistry Unit, Canterbury Health Laboratories, Christchurch, New Zealand
  1. Correspondence to:
 Dr Florkowski; 
 chris.florkowski{at}cdhb.govt.nz
  • Received 13 November 2002
  • Accepted 19 December 2002

Abstract

A woman was screened for diabetes using glycated haemoglobin (HbA1c). Vastly different results were obtained by high performance liquid chromatography (45%), immunoassay (2.9%), and affinity chromatography (4.2%) compared with the non-diabetic range of less than 6.4%. Mass spectral studies confirmed the presence a haemoglobin variant, haemoglobin Marseille-Long Island which had confounded interpretation by all methods.

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