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Postgrad Med J 2002;78:752-753 doi:10.1136/pmj.78.926.752
  • Case report

Presentation of a PTHrP-secreting pancreatic neuroendocrine tumour, with hypercalcaemic crisis, pre-eclampsia, and renal failure

  1. P Abraham1,
  2. S H Ralston1,
  3. M Hewison2,
  4. W D Fraser3,
  5. J S Bevan1
  1. 1Departments of Endocrinology, Aberdeen Royal Infirmary, Foresterhill, Aberdeen
  2. 2Department of Medicine, University of Birmingham, Queen Elizabeth Hospital, Birmingham
  3. 3Department of Clinical Chemistry, Royal Liverpool University Hospital, Liverpool
  1. Correspondence to:
 Dr P Abraham, Ward 27/28, Aberdeen Royal Infirmary, Foresterhill, Aberdeen AB25 2ZN, UK;
 p.abraham{at}arh.grampian.scot.nhs.uk
  • Received 31 August 2002
  • Accepted 30 September 2002

Abstract

Severe hypercalcaemia during pregnancy is rare and most cases are secondary to hyperparathyroidism. This is the first report of a parathyroid hormone related protein (PTHrP) secreting neuroendocrine tumour of the pancreas manifesting with severe hypercalcaemia during pregnancy. Measurement of PTHrP was useful in both the diagnosis and follow up of our patient and should be considered in the diagnostic workup of patients with unexplained hypercalcaemia. A raised PTHrP concentration is a strong indicator of malignancy.

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