Improving the utility of prostate specific antigen (PSA) in the diagnosis of prostate cancer: the use of PSA derivatives and novel markers
- Correspondence to: Mr Sunjay Jain, Division of Urology, University of Leicester, Leicester General Hospital, Gwendolen Road, Leicester, LE5 4PW, UK; sj34{at}le.ac.uk
- Received 28 May 2002
- Accepted 22 July 2002
Abstract
Prostate specific antigen (PSA) testing is now a routine part of the investigation of men with suspected prostate cancer. While a very useful test it still has its problems, in particular its lack of specificity means abnormal results are often caused by benign disease. This review describes the current problems with PSA testing in prostate cancer diagnosis and highlights potential ways in which these may be reduced.
- ACT, alpha-1-antichymotrypsin
- A2M, alpha-2-macroglobulin
- API, alpha-1-trypsin (or protein) inhibitor
- BPH, benign prostatic hyperplasia
- fPSA, free PSA
- hK2, human kallikrein 2
- hK3, human kallikrein 3
- PSA, prostate specific antigen
- PSMA
- prostate specific membrane antigen
- tPSA, total PSA







