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Postgrad Med J 2002;78:564-565 doi:10.1136/pmj.78.923.564
  • Case report

Enzyme replacement therapy in the management of longstanding skeletal and soft tissue salmonella infection in a patient with Gaucher’s disease

  1. M Margalit1,
  2. N Ash2,
  3. A Zimran1,
  4. H Halkin3
  1. 1Gaucher Clinic, Shaare Zedek Medical, Jerusalem, Israel
  2. 2Department of Internal Medicine A, Chaim Sheba Medical Center, Tel Hashomer, Israel
  3. 3Division of Clinical Pharmacology and Toxicology
  1. Correspondence to:
 Dr Ari Zimran, Gaucher Clinic, Shaare Zedek Medical Center, POB 3235, Jerusalem 91031, Israel;
 zimran{at}md2.huji.ac.il
  • Received 6 December 2001
  • Accepted 29 May 2002

Abstract

A splenectomised patient with Gaucher’s disease who developed multiple foci of osteomyelitis and soft tissue abcesses, after a severe episode of group C salmonella sepsis, is described. Aggressive antibiotic treatment and surgical drainage had little effect and the patient’s condition continued to deteriorate. With initiation of enzyme replacement therapy (ERT) in addition to specific antibiotic treatment, defervescence and gradual healing occurred. Complete resolution of the infection was seen after 15 months. The possible role of ERT in healing bacterial infections in Gaucher’s disease is discussed.

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