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Postgrad Med J 2002;78:439-440 doi:10.1136/pmj.78.921.439
  • ADVERSE DRUG REACTIONS

Fatal haemorrhagic pulmonary oedema and associated angioedema after the ingestion of rofecoxib

  1. N P Kumar1,
  2. G Wild2,
  3. K A Ramasamy1,
  4. J Snape1
  1. 1General and Geriatric Medicine, King’s Mill Hospital, Sutton in Ashfield, Nottinghamshire, UK
  2. 2Protein Reference Unit, Northern General Hospital, Sheffield, UK
  1. Correspondence to:
 Dr Jeremy Snape, King’s Mill Centre, Mansfield Road, Sutton in Ashfield, Notts NG17 4JL, UK;
 jayne.morton{at}mch.cnhc-tr.trent.nhs.uk
  • Received 28 August 2001
  • Accepted 26 March 2002

Abstract

Angioedema is a recognised side effect of rofecoxib, a cyclo-oxygenase-2 (COX-2) inhibitor. But death resulting from a haemorrhagic pulmonary oedema after its ingestion has not been recorded. The case of a 60 year old man who died from haemorrhagic pulmonary oedema in the presence of angioedema after the ingestion of two doses of 12.5 mg of rofecoxib is reported.

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