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Answers on p 588.
A 54 year old white male first presented in 1978 to the medical department of the hospital with a six month history of shortness of breath and productive cough. His symptoms became progressively worse and necessitated two hospital admissions. He had vitiligo for 14 years and hereditary icthyosis. He was a non-smoker and he worked in a chemical factory with lacquers and thinners.
Examination revealed both inspiratory and expiratory wheeze and a few crepitations at the right lung base. Abdominal examination showed a palpable spleen of about 8 cm and a palpable liver of about 6 cm below the costal margin. Investigation confirmed angiotensin converting enzyme of 72 IU (normal range 10–65). The chest radiograph is shown in fig 1 and the respiratory function showed a mixed obstructive and restrictive picture. Bronchoscopy revealed hyperaemic mucosa which was irregular with white “cobblestoning” and there was narrowing of both bronchi compatible with endobronchial sarcoidosis. The Kveim test was positive and lymph node biopsy confirmed sarcoidosis. He had maintenance doses of steroids varying between 5 mg and 25 mg daily for 18 years until remission of symptoms about two years before.
He was referred to the ear, nose, and throat department in November 1997 with deafness in the left ear which followed an ear infection. Examination of the ears showed a dull tympanic membrane on the left while the right side was normal. Pure tone audiometry showed mild bilateral high tone sensorineural hearing loss and an additional conductive loss in the left ear. The tympanogram showed type B tracing in the left ear. He had a left myringotomy and grommet insertion. Examination of the postnasal space was normal on visual inspection and palpation. A random biopsy was performed and tissue from the left side of the postnasal space revealed hyperplastic lymphoid tissue in which there were some active germinal centres. There were several discrete epithelioid granuloma containing Schaumann bodies including some Langhans type multinucleated giant cells. There was no caseous necrosis or special giant cells. Special stains failed to reveal any fungi or acid fast bacilli. There was no evidence of malignancy and the histological finding was in keeping with sarcoidosis (figs 2 and3).
- What is the differential diagnosis?
- What does the chest radiograph show?
- What is the cause of deafness in the left ear?
- What are the otolaryngological manifestations of sarcoidosis?