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Postgrad Med J 2000;76:333-336 doi:10.1136/pmj.76.896.333
  • Review

Progressive supranuclear palsy

  1. H U Rehman
  1. Hull Royal Infirmary, Anlaby Road, Hull HU3 2JZ, UK
  1. Dr Rehman
  • Received 20 April 1999
  • Accepted 22 September 1999

Abstract

Progressive supranuclear palsy (PSP) or Steele-Richardson-Olszewski syndrome is a neurodegenerative disease of middle and late age. It is under-diagnosed not only by general physicians but also by neurologists. The cause of PSP is not known. Exposure to toxins and viruses has been proposed in the aetiology of PSP without any concrete evidence. The features of PSP resemble those of Parkinson's disease and the two diseases are often confused. Corticobasal degeneration and multisystem atrophy are other differential diagnoses. Despite certain common features with Parkinson's disease, corticobasal degeneration, and mutisystem atrophy, there are important differences that help to differentiate it from these disorders.

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