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Postgrad Med J 1999;75:297-298 doi:10.1136/pgmj.75.883.297
  • Short report

Massive pleural effusions in cryptococcal meningitis

  1. C M M Wong,
  2. K H Lim,
  3. C K Liam
  1. Department of Medicine, University Hospital, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
    • Accepted 19 November 1998

    Abstract

    Cryptococcal infection uncommonly presents with pulmonary manifestations and even more rarely so as massive bilateral effusions. Pleural involvement is usually associated with underlying pulmonary parenchymal lesions and is unusual while on antifungal therapy. We report a patient with cryptococcal meningitis who, while on intravenous 5-flucytosine and amphotericin B, developed life-threatening bilateral massive pleural effusions with evidence of spontaneous resolution, consistent with prior hypothesis of antigenic stimulation as the cause of pleural involvement.

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