Small bowel obstruction in a young adult
- Mr DW Harkin, Specialist Registrar General Surgery, 37 Wynchurch Terrace, Rosetta, Belfast BT6 OHP, Northern Ireland
- Accepted 21 July 1998
A 21-year-old man presented to hospital with a 3-day history of increasing vomiting, abdominal pain and distension, and constipation. On questioning, he gave a 3-month history of poor appetite, intermittent abdominal cramps, intermittent diarrhoea and weight loss of approximately 13 kg. He had no relevant medical or family history, and had no previous surgery. He was apyrexic clinically anaemic, with a centrally distended abdomen, but no abdominal scars or external hernia. Bowel sounds were obstructive but there were no obvious signs of peritonism. Positive blood results showed a microcytic hypochromic anaemia (haemoglobin 7.9 g/dl) and a low serum albumin (corrected albumin 26 g/l), his inflammatory markers were also grossly elevated (C-reactive protein (CRP) 112 IU/l; erythrocyte sedimentation rate 77). Erect and supine abdominal X-rays are shown in figures 1 and2.
- What do the abdominal X-rays show (figures 1 and 2)?
- What is the differential diagnosis?
- What is the most appropriate treatment?
The erect abdominal X-ray (figure 1) shows a large air-filled viscus in the upper abdomen with two long fluid levels. The supine abdominal X-ray (figure 2) shows several grossly dilated small bowel loops in the central upper abdomen. No obvious free intra-peritoneal gas is seen outlining the ligamentum teres, major viscus, paracolic gutters, or between adjacent bowel loops (Riggler's sign) on either X-ray. An erect chest film also showed no subdiapragmatic air.
The differential diagnosis is small bowel obstruction (adhesions, hernia, tumour, inflammatory stricture, foreign body, gallstone, congenital bands or stenosis, intussusception, meconium ileus or meconium ileus equivalent, mid-gut volvulus), large bowel obstruction (tumour, volvulus, inflammatory stricture), or gastric dilation (acute, outlet obstruction, volvulus).
The distribution of the distended bowel loop in the central upper abdomen, the presence of valvulae conniventes, and the absence of gaseous distension of the caecum implies small bowel obstruction. The size of the distended bowel loop may imply an acute on chronic obstruction.
He underwent a surgical laparotomy which revealed an obstructed and grossly dilated 25 cm segment of mid small bowel twisted 360° clockwise about its mesentery (figure 3). The segment of small bowel was grossly dilated with diameter in excess of 10 cm, but was not acutely ischaemic, and there were many large reactive lymph nodes in its draining mesentery. There was no evidence of malrotation or situs-inversus, and there were no abnormal fibrous or Ladd's bands. We performed a wide segmental resection and side-to-side anastamosis of his small bowel. He made an uncomplicated post-operative recovery.
Histopathology showed a gross specimen of 25 cm of dilated small bowel, diameter in excess of 10 cm, with four large ulcerated areas on the mucosal surface and unremarkable mucosa in between. The mesentery also contained two large reactive lymph nodes. On histological examination the areas of mucosal ulceration contained fissure ulcers, transmural chronic ulceration, lymphoid follicle formation, and submucosal fibrosis. Areas of normal mucosa separated the involved segments. Despite the absence of granulomata, histopathological features were consistent with Crohn's disease.
Our patient is presently under review on sulphasalazine treatment, and has had no major disease flare-ups or symptoms one year post operation.
Crohn's disease is a chronic, transmural, inflammatory, disease of the intestinal tract most frequently involving the terminal ileum and colon. The disease can affect any part of the gastrointestinal tract from lips to anus, and also can manifest itself as various systemic complications such as finger clubbing, large joint arthritis, erythema nodosum, iritis, pyoderma gangrenosum, episcleritis, uveitis and conjunctivitis, sclerosing cholangitis and bile duct carcinoma, although liver problems are much more common in ulcerative colitis.1 2 There is a wide geographical variation in the incidence of Crohn's disease, and although the aetiology is unknown, there does appear to be some genetic susceptibility as there is a 30-fold increase in sibling incidence compared to the general population. The most common symptoms of small bowel Crohn's disease are diarrhoea (90%), abdominal pains (55%), anorexia, nausea and weight loss (22%).1 2 Our patient exhibited all these symptoms, and also showed typical nutritional disturbance of anaemia (iron, folate or vitamin B12 deficiency), hypoalbuminaemia and weight loss. Acute phase reactants are also often raised in active disease and our patient's CRP was grossly elevated. Small bowel stenosis is common in Crohn's disease, at time of diagnosis a bowel stenosis was documented in 37% in one series.3 However, acute first presentation of Crohn's disease with small bowel segmental volvulus has not previously been reported. Closed loop obstruction such as this can also lead to accelerated mucosal permeability changes with bacterial translocation and portal endotoxaemia which may lead to multiple organ dysfunction syndrome. Also grossly distended bowel is at risk of ischaemic necrosis and/or perforation.3 Therefore, early diagnosis and expedient treatment is a priority to prevent the development of these complications. Small bowel volvulus (midgut volvulus) is in itself rare and usually presents in childhood, being due to an unusually narrow based mesentery to the small bowel caused by malrotation of the bowel and persistent embryological peritoneal bands (Ladd's bands). In the absence of this embryological abnormality, volvulus of small bowel is extremely rare. However, in our case, there was no malrotation and rather the volvulus occurred by twisting of a grossly dilated loop of small bowel about an area of inflammatory stenosis of the small bowel. With short segment stenosis due to Crohn's disease, the conservative procedure of stricturoplasty has been very effective with a low associated morbidity and mortality.4 In our patient however, due to the extent of the disease in the involved segment and the lack of a prior histological diagnosis, a segmental resection was felt to be appropriate.
Clinicians should be aware of this rare presentation, demonstrated on abdominal X-ray, which required quick diagnosis and urgent treatment. This report adds to the known literature on both Crohn's disease and small bowel volvulus.
Crohn's disease can present in a variety of ways and mimic many other disease processes. It should be part of every clinician's differential diagnosis of acute or chronic abdominal pain
a closed loop bowel obstruction is a surgical emergency which requires rapid diagnosis and early intervention, if a successful outcome is to be obtained
true midgut volvulus not only presents in children, but although rare, has been reported in young adults and even geriatrics
in the absence of congenital abnormalities, a volvulus can occur around any pivotal point; common axes for the volvulus are tumours, adhesive bands, and stenoses
Crohn's disease presenting as a segmental small bowel volvulus.