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Postgrad Med J 1999;75:67-73 doi:10.1136/pgmj.75.880.67
  • Review
  • Current concepts

Osmosis, osmometry, and osmoregulation

  1. R C C Lord
  1. Department of Clinical Chemistry, Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, UK
    • Accepted 2 September 1998

    Abstract

    The maintenance of adequate body fluid volume and the correct distribution of this fluid between the body compartments is a critical part of homeostasis. The process of osmosis plays an important role in movement of fluid within the body and the use of osmometry is an important part of the management of many patients. In addition to the application of osmometry to the measurement of body fluids, most commonly plasma and urine, osmotic action plays a part in some therapeutic actions of drugs and its strength needs to be quantified in fluids administered to patients. Unfortunately confusion often exists in the various terms that are used in the field of osmometry. This review aims to explain the different terms used, the laboratory methodology involved in osmometry, and the clinical application and interpretation of the results obtained.

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