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Treatment of hyperemesis gravidarum with the 5-HT3 antagonist ondansetron (Zofran).
  1. D. G. Tincello,
  2. M. J. Johnstone
  1. Department of Obstetrics and Gynaecology, Fazakerley Hospital, Liverpool, UK.

    Abstract

    Ondansetron is a 5-hydroxytryptamine receptor antagonist which is known to be a highly effective anti-emetic drug for chemotherapy-associated nausea and vomiting and for postoperative nausea. We report here a case where ondansetron was used in severe hyperemesis gravidarum to avoid parenteral nutrition. The drug was used intermittently in every trimester with no apparent adverse effects on mother or infant.

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