Postgrad Med J 69:624-626 doi:10.1136/pgmj.69.814.624
  • Research Article

Naftidrofuryl treatment for rest cramp.

  1. J. B. Young,
  2. M. J. Connolly
  1. St Luke's Hospital, Bradford, UK.


      A double-blind placebo-controlled study was carried out in 14 subjects to investigate the effect of naftidrofuryl in the treatment of rest cramp. Naftidrofuryl caused a significant reduction in cramp frequency (median naftidrofuryl = 5; median placebo = 17; P < 0.004) and a significant 34% increase in cramp free days (median naftidrofuryl = 22; median placebo = 14; P < 0.004). Naftidrofuryl is an effective alternative to quinine in the treatment of this painful condition.