Article Text


Complex neuromuscular disorder in a patient with chronic myeloid leukaemia.
  1. P. S. Bergin,
  2. A. N. Gale
  1. Royal Free Hospital, London, UK.


    We report a 44 year old man who developed external ophthalmoplegia and predominantly respiratory, truncal and bulbar weakness with brisk reflexes, histological evidence of an inflammatory myopathy and a high titre of acetylcholine receptor antibodies, one month after starting hydroxyurea and allopurinol for chronic myeloid leukaemia. The temporal relationship suggests a possible association between this patient's unusual neuromuscular disorder and either the chronic myeloid leukaemia or its treatment.

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