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Recurrent intra-cranial granulomata presenting as space-occupying lesions in a patient with common variable immunodeficiency.
  1. S. A. Misbah,
  2. G. P. Spickett,
  3. M. M. Esiri,
  4. J. T. Hughes,
  5. W. B. Matthews,
  6. R. A. Thompson,
  7. H. M. Chapel
  1. Department of Immunology, John Radcliffe Hospital, Oxford, UK.


    A patient with profound panhypogammaglobulinaemia due to common variable immunodeficiency developed two discrete intra-cranial space-occupying lesions, 10 years apart, requiring craniotomy. Histological examination revealed the intra-cranial masses to be granulomata of unknown aetiology on both occasions.

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