Article Text


Testotoxicosis: gonadotrophin-independent male sexual precocity.
  1. A. A. Aziz,
  2. S. M. Jafri,
  3. N. U. Haque
  1. Department of Medicine, Aga Khan University Hospital, Karachi, Pakistan.


    In this era of rapidly developing investigational tools and pharmacology, the pathophysiology of precocious puberty is becoming well defined. What was previously thought to be a form of gonadotrophin releasing hormone (GNRH)-dependent central precocious puberty is now classified as GNRH-independent familial testotoxicosis. We present two such cases and review the clinical features, pathophysiology and treatment of testotoxicosis.

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