Article Text

PDF

Giant lymph node hyperplasia (Castleman's disease): a clinical study of eight patients.
  1. Y. Baruch,
  2. Y. Ben-Arie,
  3. H. Kerner,
  4. M. Lorber,
  5. L. A. Best,
  6. R. Gershoni-Baruch
  1. Department of Internal Medicine B, Rambam Medical Center, Haifa, Israel.

    Abstract

    We report on 8 patients with giant lymph node hyperplasia (GLNH), diagnosed over a 10-year period. The age of the patients at diagnosis, the clinical presentation and the histological subtype varied, indicating that GNLH is a heterogeneous condition. One case was associated with liver cirrhosis, and in another patient bacterial endocarditis was diagnosed post mortem. Our study shows that GLNH is localized and benign in the young, and diffuse and aggressive in the elderly. It is concluded that GLNH should be separated into 3 clinical entities--namely, localized, systemic and reactive GLNH--defined by their clinical presentation and course, and correlated or not correlated with the histological findings.

    Statistics from Altmetric.com

    Request permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.