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Malignant fibrous histiocytoma of sternum: an unusual cause of pyrexia of undetermined origin.
  1. A. Grieco,
  2. S. Caputo,
  3. E. Silvestri,
  4. P. Caradonna,
  5. A. Bertoli,
  6. A. V. Greco
  1. Istituto di Clinica Medica Generale e Terapia Medica, Università Cattolica del Sacro Cuore, Rome, Italy.


    Malignant fibrous histiocytoma of the bone is a very rare tumour mainly affecting long bones, and the most common presenting symptom is local pain. A case of malignant fibrous histiocytoma presenting with pyrexia of undetermined origin and arising in the sternum, a localization not previously described, is reported. The patient died with septic shock after multi-drug chemotherapy including high dose methotrexate treatment with citrovorum factor rescue.

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