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Red cell folate concentrations in patients with Crohn's disease on parenteral nutrition.
  1. M. Tominaga,
  2. M. Iida,
  3. K. Aoyagi,
  4. N. Kohrogi,
  5. T. Matsui,
  6. M. Fujishima
  1. Second Department of Internal Medicine, Faculty of Medicine, Kyushi University, Fukuoka, Japan.

    Abstract

    To examine changes in the folate concentrations in red cell during relatively long-term total parenteral nutrition (TPN), 10 Japanese patients with Crohn's disease (7 males), the mean Crohn's disease activity index on admission being 211, were given folic acid in a dose of 400 micrograms/day (AMA-FDA formulation) or 800 micrograms/day for 6-16 weeks (mean 10.5). The red cell folate concentrations were determined before TPN and once every week or 2-4 weeks thereafter. The folate concentrations were very low even after TPN with folic acid of 400 micrograms/day. In those given 800 micrograms of daily folic acid, the folate levels tended to increase, but did not reach the normal range. We propose that folic acid over 800 micrograms/day or a double dose of AMA-FDA formulation should be prescribed for Crohn's disease treated with long-term TPN.

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