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Failure of penicillin prophylaxis in laboratory acquired leptospirosis.
  1. C. F. Gilks,
  2. H. P. Lambert,
  3. E. S. Broughton,
  4. C. C. Baker
  1. St. George's Hospital, London, UK.

    Abstract

    A laboratory technician developed leptospirosis following accidental inoculation, despite prompt administration of parenteral penicillin by an accepted regimen of post-exposure prophylaxis. Another technician was similarly exposed and was given doxycycline; no illness or serological conversion followed. The implications of these cases are discussed and recommendations made for post-exposure chemoprophylaxis with doxycycline.

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