We describe a patient who presented with oedema and hypoproteinaemia which was proved to be due to protein-losing enteropathy. Extensive gastrointestinal investigations failed to discover any definitive cause. He subsequently developed tuberculous inguinal lymphadenopathy but although treated for tuberculosis the protein-losing state persisted. Later on he developed renal failure due to obstructive nephropathy. Laparotomy was carried out and it disclosed the diagnosis of non-Hodgkin's lymphoma, treatment of which cured the protein-losing state.