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Haemodynamic evaluation of diastolic abnormalities in hypertrophic cardiomyopathy
  1. William Grossman,
  2. Walter Paulus,
  3. Beverly H. Lorell

    Abstract

    Haemodynamic studies suggest that an important abnormality in diastolic relaxation is characteristic of advanced hypertrophic cardiomyopathy. Current evidence supports the concept that cytosolic Ca++ overload is the pathophysiological basis for this impaired relaxation, and may in turn represent impaired membrane Ca++ pumping activity.

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