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Endralazine in patients with severe hypertension and renal insufficiency
  1. E. R. Higgs,
  2. R. A. Banks,
  3. P. R. Harrison,
  4. J. C. Kingswood,
  5. J. C. Mackenzie


    Endralazine, a new peripheral vasodilator, was given in conjunction with a beta-blocker to 21 patients with hypertension and chronic renal failure. All subjects were either poorly controlled on their previous antihypertensive regime or were experiencing unacceptable adverse effects from drugs. After 4 weeks blood pressure was reduced in all patients and symptomatic side effects were few. Two patients became anti-nuclear factor (ANF) positive in weak titre but without evidence of the lupus syndrome.

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