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Partial end organ resistance to thyroid hormone in congenital hypothyroidism
  1. John M. C. Connell,
  2. E. H. McLaren

    Abstract

    End organ resistance to thyroid hormone has been described for a number of years: the defect may be partial or generalized. A case of partial end organ resistance to thyroid hormone in congenital hypothyroidism is described, with evidence of an alteration in TSH threshold to feedback inhibition by thyroid hormone. The implications of this factor in the management of hypothyroidism are discussed.

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