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A single-dose comparison of four slow-release theophylline preparations in normal subjects
  1. J. N. Sharma,
  2. A. Blackett,
  3. A. Johnston,
  4. N. R. Hathway

    Abstract

    The plasma theophylline concentrations produced by 4 different slow release formulations, Theograd, Theodur, Theolair-SR and Rona-slophylline were measured over a 24-hr period in 8 healthy subjects. All 4 preparations maintained plasma levels over 12 hr and had similar AUC values when the difference in theophylline content was taken into account. Paired saliva and plasma theophylline concentrations gave a ratio of 1: 0·38, saliva: plasma, but with a large inter and intra individual variation.

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