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Dose response for blood pressure and degree of cardiac beta-blockade with atenolol.
  1. A. J. Marshall,
  2. D. W. Barritt,
  3. S. Heaton,
  4. J. D. Harry

    Abstract

    The hypotensive effect of 25 mg, 50 mg, 75 mg, 100 mg and 0 mg of atenolol daily were compared in a double-blind within-patient study. The fall in blood pressure with 25 mg daily was not significantly different than with 100 mg. The dose response curve lies between 0 and 25 mg daily. Cardiac beta-blockade (measured by suppression of exercise tachycardia) was not maximal with 25 mg of atenolol daily. The dose response curves for beta-blockade and the hypotensive effect are not parallel.

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