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Fetal drug syndromes
  1. Neil Gordon

    Abstract

    Certain drugs which affect fetal development are considered. Phenytoin taken during pregnancy may result in infants who remain mentally and physically retarded, with abnormal craniofacial appearance and limb defects. A boy with such a syndrome is reported. Trimethadione is another drug which has been said to be teratogenic, and to cause a typical phenotype which is described. The fetal alcohol syndrome is now well recognized and has similar features to those related to anti-epileptic drugs taken during pregnancy. A high level of suspicion of possible associations between congenital defects and drugs must be maintained.

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