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Penetration of digoxin into cerebrospinal fluid.
  1. G. D. Schott,
  2. D. W. Holt,
  3. A. M. Hayler

    Abstract

    The concentration of digoxin in the cerebrospinal fluid (CSF) of ten patients receiving conventional oral doses of this cardiac glycoside has been measured by a radioimmunoassay technique. Digoxin was undetected in eight patients and barely detectable in two, suggesting the presence of a significant blood-CSF barrier for digoxin. The implication of these findings is discussed.

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