A case of subacute bacterial endocarditis which was due to an α-haemolytic streptococcus is described. A therapeutic dilemma arose when the patient developed a drug fever to penicillin and was found to be allergic to cephalosporine. Oral clindamycin was used, but had to be abandoned since severe exacerbation of an unsuspected duodenal ulcer resulted. The patient was finally successfully treated with clindamycin-2-phosphate, a new injectable form of the drug, and the success of this therapy is documented.
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