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Assessment of vaccine efficacy by challenge studies in man
  1. D. A. J. Tyrrell

    Abstract

    The only final test of the potency of a vaccine is its ability to protect against exposure in an epidemic. Laboratory tests for control purposes attempt to predict this capacity. It is suggested that challenging small groups of volunteers with attenuated influenza virus is a good index of immunity which could be used to check and refine present tests and to evaluate new ones.

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