Postgrad Med J 51:770-773 doi:10.1136/pgmj.51.601.770
  • Lead Symposium
    • Session I

Kinetics of lead interaction with human erythrocytes


The kinetics of the interaction of lead with human erythrocytes has been investigated in vitro by means of tracer studies with 203Pb. The elution characteristics of lead from erythrocytes in contact with EDTA suggest the existence of two binding sites differing in their affinity for lead. The findings are consistent with the existence of two compartments for lead binding in the cell, and a model system based on this concept is proposed.