Studies on differences of observation and interpretation between pathologists in connection with histological diagnosis are rare. The present paper gives a general account of such a study, by members of the Cancer Research Campaign's Bone Tumour Panel, of certain histological features of ‘malignant round-cell tumours’ of bone. Significant differences were found, not only between the different cases studied, but between the observations of the different pathologists, and between the repeated observations of individual pathologists.
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