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Pathogenesis of renal failure in cirrhosis and fulminant hepatic failure
  1. S. P. Wilkinson,
  2. D. Hurst,
  3. B. Portmann,
  4. Roger Williams

    Abstract

    Acute renal failure in cirrhosis and fulminant hepatic failure represents a spectrum with ‘functional renal failure’ at one end and acute tubular necrosis at the other. In fulminant hepatic failure the development of renal failure is not necessarily a measure of the severity of liver damage.

    Functional renal failure is due to active renal vasoconstriction which may, at least in fulminant hepatic failure, be initiated by systemic endotoxaemia.

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