Precipitating antibody against bacterial antigens obtained from known pathogens has been looked for in sputum of patients with chronic respiratory disease. Preliminary results suggest that detection of precipitating antibody to a cell wall extract of the organism may be important in determining its pathogenicity in a particular patient. Local antibody production appears to be important in these conditions. It is proposed that this locally produced precipitating antibody may be contributing to the underlying lung pathology.
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