Article Text

PDF

Sodium nitroprusside: theory and practice
  1. Ian R. Verner

    Abstract

    Sodium nitroprusside, by a peripheral vasodilator action, is a powerful hypotensive drug. In contrast to established agents, its hypotensive action is accompanied by an unchanged or augmented cardiac output. Intravenous administration of sodium nitroprusside rapidly produces a profound and controllable hypotension. Normotension is swiftly restored by ceasing to infuse the agent, and antidotes are unnecessary. Its attributes make it especially suitable for neurosurgical anaesthesia, and although free cyanide is liberated during biotransformation, side effects are virtually absent provided that dosage is reasonable. Special contraindications to its use are hypothyroidism and altered cobalamin metabolism.

    Statistics from Altmetric.com

    Request permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.