Article Text


Trial of a single low dose of heparin in the prevention of post-operative deep-vein thrombosis monitored by doppler ultrasound
  1. T. Bates


    A consecutive, randomly allocated, controlled, double-blind clinical trial of the prophylactic effect of a single pre-operative low dose of heparin on the incidence o-post-operative deep-vein thrombosis showed no reducf tion in the number of thromboses detected.

    Fifty-five patients were given 5000 units of heparin subcutaneously 1-1½ hr pre-operatively and fifty-seven patients were given a placebo. The incidence of thrombosis detected by the doppler ultrasound was 14·5% in the heparin group and 12·3% in the control group.

    It is suggested that a further trial monitored by ultrasound is indicated in which low-dose heparin is given for various periods post-operatively in addition to a pre-operative dose.

    Statistics from

    Request permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.