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Trial of a single low dose of heparin in the prevention of post-operative deep-vein thrombosis monitored by doppler ultrasound
  1. T. Bates

    Abstract

    A consecutive, randomly allocated, controlled, double-blind clinical trial of the prophylactic effect of a single pre-operative low dose of heparin on the incidence o-post-operative deep-vein thrombosis showed no reducf tion in the number of thromboses detected.

    Fifty-five patients were given 5000 units of heparin subcutaneously 1-1½ hr pre-operatively and fifty-seven patients were given a placebo. The incidence of thrombosis detected by the doppler ultrasound was 14·5% in the heparin group and 12·3% in the control group.

    It is suggested that a further trial monitored by ultrasound is indicated in which low-dose heparin is given for various periods post-operatively in addition to a pre-operative dose.

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