Article Text


A double-blind clinical trial of griseofulvin in patients with Raynaud's phenomenon
  1. S. Sabri,
  2. V. C. Roberts,
  3. R. F. Higgins,
  4. L. T. Cotton,
  5. D. I. Williams,
  6. L. C. Wilson


    Twenty-four patients with Raynaud's phenomenon were treated with griseofulvin and a placebo in a double-blind cross-over clinical trial. The results were assessed subjectively and plotted sequentially. The number of patients able to distinguish the active from the placebo treatment was statistically significant (P=0·05). There were indications that the response was dose dependent. Further studies are needed to establish whether griseofulvin offers useful clinical improvement in this condition.

    Statistics from

    Request permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.