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A double-blind clinical trial of griseofulvin in patients with Raynaud's phenomenon
  1. S. Sabri,
  2. V. C. Roberts,
  3. R. F. Higgins,
  4. L. T. Cotton,
  5. D. I. Williams,
  6. L. C. Wilson

    Abstract

    Twenty-four patients with Raynaud's phenomenon were treated with griseofulvin and a placebo in a double-blind cross-over clinical trial. The results were assessed subjectively and plotted sequentially. The number of patients able to distinguish the active from the placebo treatment was statistically significant (P=0·05). There were indications that the response was dose dependent. Further studies are needed to establish whether griseofulvin offers useful clinical improvement in this condition.

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