Article Text

PDF

Aminoglutethimide: a ‘side-effect’ turned to therapeutic advantage
  1. S. W. M. Hughes,
  2. D. M. Burley

    Abstract

    Aminoglutethimide was introduced as an anti-convulsant drug in the U.S.A. in 1960.

    The occurrence of a number of side-effects, including several endocrine effects such as goitrogenesis, sexual precocity and virilization, led to its withdrawal.

    Further investigation indicated that the drug inhibited adrenal biosynthesis, particularly of aldosterone, cortisol and androgens, probably by interfering with the conversion of cholesterol to delta-5-pregnenolone.

    Aminoglutethimide has also been shown to modify the extra-adrenal metabolism of cortisol.

    The possible clinical applications of these ‘side-effects’ are discussed.

    Statistics from Altmetric.com

    Request permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.